Widmer validating machines
Software implementing these improvements and the experimental comparisons are available at
There has been a great deal of interest in statistical methods for genome-wide association studies (GWAS).
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LMMs rely on the estimation of a genetic similarity matrix (GSM), which encodes the pairwise similarity between every two individuals in a cohort.
One important motivation for more sophisticated models is the existence of confounding structure, including population structure and family relatedness.This whitepaper discusses the four mandatory components for the correct validation of machine learning models, and how correct model validation works inside Rapid Miner Studio.